Prevention Of Alzheimer's Disease Pathology By Cannabinoids: Neuroprotection Mediated By Blockade Of Microglial Activation

Alzheimer's Disease

Key Findings

Neuroprotective in AD. Intracerebroventricular administration of the synthetic cannabinoid WIN55,212-2 to rats prevented beta-amyloid peptide-induced microglial activation, cognitive impairment, and loss of neuronal markers.

Information and Links


Link: Prevention Of Alzheimer's Disease Pathology By Cannabinoids: Neuroprotection Mediated By Blockade Of Microglial Activation

Year: 2005

DOI: 10.1523/JNEUROSCI.4540-04.2005


Ratings

(How Ratings Work)

Alzheimer's Disease — 2


Possible to probable range of efficacy of cannabis for treatment of Alzheimer's Disease according to the results found in this study.

Drugs Used

WIN55,212-2, HU210, and JWH-133